Chronic Hypoplastic Neutropenia

Acquired chronic neutropenia.

Neutrophil kinetics in chronic neutropenia.

Quantitative studies of bone marrow neutrophil pool sizes and production rates and of blood neutrophil kinetics were performed in 16 patients with chronic neutropenia without splenomegaly. Marrow netrophil cellularity was determined from a ferrokinetic estimate of marrow normoblasts and from neutrophil-erythroid ratios determined from marrow sections. Postmitotic pool turnover was derived from ...

Chronic hypoplastic anaemia arising in infancy.

An aplasia of the erythroblastic tissue in the bone marrow, without involvement of either leucocytes or platelets, is referred to by Whitby and Britton (1946) as a medical curiosity. This aplasia may be complete or partial. If complete, there is no formation of normal red-cell precursors. Strictly speaking, the term 'aplastic anaia ' should be reserved for cases of this kind, where there is a p...

Chronic benign neutropenia among Chinese children.

OBJECTIVE To delineate the clinical behaviour of chronic benign neutropenia in Chinese children in Hong Kong. DESIGN Retrospective study. SETTING University teaching hospital, Hong Kong. PATIENTS All infants and children with absolute neutrophil count of 1.5 x 10(9) /L or lower for more than 3 months. MAIN OUTCOME MEASURES Development of significant infection, and achievement of remissi...

Chronic neutropenia mediated by fas ligand.

Chronic neutropenia, often associated with rheumatoid arthritis, is a characteristic finding in large granular lymphocyte (LGL) leukemia. The mechanism of neutropenia is not known. Normal neutrophil survival is regulated by the Fas-Fas ligand apoptotic system. We hypothesized that neutropenia in LGL leukemia is mediated by dysregulated expression of Fas ligand. Levels of Fas ligand in serum sam...